Title : Musashi 1-positive cells derived from mouse embryonic stem cells treated with LY294002 are prone to differentiate into intestinal epithelial-like tissues.

Pub. Date : 2019 Jun

PMID : 30942388






5 Functional Relationships(s)
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1 Musashi 1-positive cells derived from mouse embryonic stem cells treated with LY294002 are prone to differentiate into intestinal epithelial-like tissues. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one musashi RNA-binding protein 1 Mus musculus
2 A pMsi1-green fluorescence protein reporter plasmid was used to sort the Msi1-positive cells from mESCs treated and untreated with LY294002 (5 micromol/l). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one musashi RNA-binding protein 1 Mus musculus
3 Compared with the Msi1-positive cells derived from mESCs without LY294002 treatment, Msi1-positive cells derived from mESCs treated with LY294002 expressed higher levels of leucine-rich repeat-containing G-protein coupled receptor, a marker of intestinal epithelial stem cells, and lower levels of Nestin, a marker of neural epithelial stem cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one musashi RNA-binding protein 1 Mus musculus
4 The grafts from Msi1-positive cells treated with LY294002 contained more intestinal epithelial-like tissues and fewer neural epithelial-like tissues, compared with those from untreated Msi1-positive cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one musashi RNA-binding protein 1 Mus musculus
5 The Msi1-positive cells selected from the cell population derived from mESCs treated with LY294002 exhibited more characteristics of intestinal epithelial stem cells than those from the untreated group. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one musashi RNA-binding protein 1 Mus musculus