Title : Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors.

Pub. Date : 2019 Mar 1

PMID : 30718063






1 Functional Relationships(s)
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1 To discover new, potent, and selective inhibitors for the murine gamma-aminobutyric acid transporter 4 (mGAT4), the structure-activity relationship (SAR) study of a new cis-alkene analog family based on DDPM-1457 [(S)-2], which previously showed promising inhibitory potency at and subtype selectivity for mGAT4, was conducted. gamma-Aminobutyric Acid solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus