Pub. Date : 2019 Apr 1
PMID : 30651358
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA). | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine | ankyrin repeat, SAM and basic leucine zipper domain containing 1 | Homo sapiens |
2 | We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA). | 4-phenylbutyric acid | ankyrin repeat, SAM and basic leucine zipper domain containing 1 | Homo sapiens |
3 | We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA). | 4-phenylbutyric acid | ankyrin repeat, SAM and basic leucine zipper domain containing 1 | Homo sapiens |
4 | We propose that PCV2-driven ER stress is Cap dependent and could lead to mitochondrial apoptotic responses independent of ORF3 via perturbation of intracellular Ca2+ homeostasis and accumulation of ROS.IMPORTANCE PCV2 encodes protein ORF3, a putative protein with proapoptotic activity. | Reactive Oxygen Species | ankyrin repeat, SAM and basic leucine zipper domain containing 1 | Homo sapiens |
5 | Here we clearly show that PCV2 infection or Cap expression induces ORF3-independent apoptosis via increased cytosolic and mitochondrial Ca2+ levels and cellular ROS levels as a result of activation of the PERK pathway. | Reactive Oxygen Species | ankyrin repeat, SAM and basic leucine zipper domain containing 1 | Homo sapiens |