PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine	137-147	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-23	
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine	137-147	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	124-128	
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	4-phenylbutyric acid	190-206	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-23	
30651358-7	2019	We found that DeltaORF3-induced apoptosis was significantly reduced when the infected cells were treated with the selective PERK blocker GSK2606414 (GSK) or the general ER stress attenuator 4-phenylbutyrate (4-PBA).	4-phenylbutyric acid	208-213	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-23	
30651358-10	2019	With transient expression of the structural protein capsid (Cap) in combination with PERK silencing, we found that Cap induced MMP collapse and mitochondrial apoptosis could result from the UPR and elevation of Ca2+ and ROS levels, which were inhibitable by downregulation of PERK.	Reactive Oxygen Species	220-223	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	276-280	
30651358-11	2019	We propose that PCV2-driven ER stress is Cap dependent and could lead to mitochondrial apoptotic responses independent of ORF3 via perturbation of intracellular Ca2+ homeostasis and accumulation of ROS.IMPORTANCE PCV2 encodes protein ORF3, a putative protein with proapoptotic activity.	Reactive Oxygen Species	198-201	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	234-238	
30651358-12	2019	Our early studies showed that PCV2 infection triggers ER stress via selective activation of the PERK pathway, a branch of the ER stress pathways, in permissive cells for enhanced replication and infection increased cytosolic Ca2+ and ROS levels.	Reactive Oxygen Species	234-237	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	96-100	
30651358-13	2019	Here we clearly show that PCV2 infection or Cap expression induces ORF3-independent apoptosis via increased cytosolic and mitochondrial Ca2+ levels and cellular ROS levels as a result of activation of the PERK pathway.	Reactive Oxygen Species	161-164	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	67-71	
30651358-13	2019	Here we clearly show that PCV2 infection or Cap expression induces ORF3-independent apoptosis via increased cytosolic and mitochondrial Ca2+ levels and cellular ROS levels as a result of activation of the PERK pathway.	Reactive Oxygen Species	161-164	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	205-209