Pub. Date : 2019 Feb
PMID : 30569136
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-223-3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro. | Dexmedetomidine | TIA1 cytotoxic granule associated RNA binding protein like 1 | Homo sapiens |
| 2 | Furthermore, treatment with H2O2 inhibited the expression of mir-223-3p and enhanced the expression of its target cytotoxic granule associated RNA binding protein like 1 (TIAL1), and these effects were reversed by treatment with DEX. | Hydrogen Peroxide | TIA1 cytotoxic granule associated RNA binding protein like 1 | Homo sapiens |
| 3 | Furthermore, treatment with H2O2 inhibited the expression of mir-223-3p and enhanced the expression of its target cytotoxic granule associated RNA binding protein like 1 (TIAL1), and these effects were reversed by treatment with DEX. | Dexmedetomidine | TIA1 cytotoxic granule associated RNA binding protein like 1 | Homo sapiens |
| 4 | The results of the present study demonstrated that DEX may induce its neuroprotective effects by regulating the interaction between miR-223-3p and TIAL1. | Dexmedetomidine | TIA1 cytotoxic granule associated RNA binding protein like 1 | Homo sapiens |
| 5 | Therefore, the manipulation of miR-223-3p/TIAL1 interaction may be involved in the neuroprotective effects of DEX. | Dexmedetomidine | TIA1 cytotoxic granule associated RNA binding protein like 1 | Homo sapiens |