Pub. Date : 1987 Sep 15
PMID : 3040755
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The activity of A-SMase was 16% lower in cells incubated with gentamicin as compared to control. | Gentamicins | sphingomyelin phosphodiesterase 1 | Homo sapiens |
| 2 | Whereas Mg2+ had no effects, Triton X-100 stimulated the activity of the A-SMase in PT cells. | Octoxynol | sphingomyelin phosphodiesterase 1 | Homo sapiens |
| 3 | The Km values for sphingomyelin using A-SMase in control cells and cells incubated with gentamicin were 0.07 X and 0.016 X 10(-7) M, respectively, whereas the Km values for sphingomyelin using N-SMase in control cells and cells incubated with gentamicin were 1.8 X and 1.5 X 10(-7) M, respectively. | Sphingomyelins | sphingomyelin phosphodiesterase 1 | Homo sapiens |
| 4 | These findings suggest that gentamicin exerts a competitive inhibition of the A-SMase in PT cells. | Gentamicins | sphingomyelin phosphodiesterase 1 | Homo sapiens |
| 5 | Cells incubated with gentamicin for 21 days contained 25% lower activity of A-SMase associated with the lysosomal fraction as compared to control. | Gentamicins | sphingomyelin phosphodiesterase 1 | Homo sapiens |