PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3040755-7 1987 The activity of A-SMase was 16% lower in cells incubated with gentamicin as compared to control. Gentamicins 62-72 sphingomyelin phosphodiesterase 1 Homo sapiens 16-23 3040755-8 1987 The most striking observation was a gradual decline in the activity of N-SMase in cells incubated with gentamicin. Gentamicins 103-113 sphingomyelin phosphodiesterase 2 Homo sapiens 71-78 3040755-9 1987 Thus, following 21 days of incubation of cells with 0.3 mM gentamicin, the N-SMase was 2.7-fold lower than control cells. Gentamicins 59-69 sphingomyelin phosphodiesterase 2 Homo sapiens 75-82 3040755-10 1987 Mg2+ stimulated and Triton X-100 inhibited the activity of N-SMase. magnesium ion 0-4 sphingomyelin phosphodiesterase 2 Homo sapiens 59-66 3040755-10 1987 Mg2+ stimulated and Triton X-100 inhibited the activity of N-SMase. Octoxynol 20-32 sphingomyelin phosphodiesterase 2 Homo sapiens 59-66 3040755-11 1987 Whereas Mg2+ had no effects, Triton X-100 stimulated the activity of the A-SMase in PT cells. Octoxynol 29-41 sphingomyelin phosphodiesterase 1 Homo sapiens 73-80 3040755-13 1987 The Km values for sphingomyelin using A-SMase in control cells and cells incubated with gentamicin were 0.07 X and 0.016 X 10(-7) M, respectively, whereas the Km values for sphingomyelin using N-SMase in control cells and cells incubated with gentamicin were 1.8 X and 1.5 X 10(-7) M, respectively. Sphingomyelins 18-31 sphingomyelin phosphodiesterase 1 Homo sapiens 38-45 3040755-13 1987 The Km values for sphingomyelin using A-SMase in control cells and cells incubated with gentamicin were 0.07 X and 0.016 X 10(-7) M, respectively, whereas the Km values for sphingomyelin using N-SMase in control cells and cells incubated with gentamicin were 1.8 X and 1.5 X 10(-7) M, respectively. Sphingomyelins 18-31 sphingomyelin phosphodiesterase 2 Homo sapiens 193-200 3040755-13 1987 The Km values for sphingomyelin using A-SMase in control cells and cells incubated with gentamicin were 0.07 X and 0.016 X 10(-7) M, respectively, whereas the Km values for sphingomyelin using N-SMase in control cells and cells incubated with gentamicin were 1.8 X and 1.5 X 10(-7) M, respectively. Gentamicins 88-98 sphingomyelin phosphodiesterase 2 Homo sapiens 193-200 3040755-14 1987 These findings suggest that gentamicin exerts a competitive inhibition of the A-SMase in PT cells. Gentamicins 28-38 sphingomyelin phosphodiesterase 1 Homo sapiens 78-85 3040755-15 1987 In contrast, gentamicin exerts a noncompetitive inhibition of the N-SMase in PT cells. Gentamicins 13-23 sphingomyelin phosphodiesterase 2 Homo sapiens 66-73 3040755-17 1987 Cells incubated with gentamicin for 21 days contained 25% lower activity of A-SMase associated with the lysosomal fraction as compared to control. Gentamicins 21-31 sphingomyelin phosphodiesterase 1 Homo sapiens 76-83