Pub. Date : 2018 Nov
PMID : 30354245
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-alpha (peroxisome proliferator-activated receptors alpha) and the orphan receptor GPR55. | palmidrol | G protein-coupled receptor 55 | Mus musculus |
| 2 | Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-alpha (peroxisome proliferator-activated receptors alpha) and the orphan receptor GPR55. | Fatty Acids | G protein-coupled receptor 55 | Mus musculus |
| 3 | Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-alpha (peroxisome proliferator-activated receptors alpha) and the orphan receptor GPR55. | Phospholipids | G protein-coupled receptor 55 | Mus musculus |
| 4 | Mechanistically, we found that palmitoylethanolamide, by activating GPR55, increases the expression of the phagocytosis receptor MerTK (proto-oncogene tyrosine-protein kinase MER) and enhances macrophage efferocytosis, indicative of proresolving properties. | palmidrol | G protein-coupled receptor 55 | Mus musculus |