Title : Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation.

Pub. Date : 2018 Nov

PMID : 30354245






4 Functional Relationships(s)
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1 Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-alpha (peroxisome proliferator-activated receptors alpha) and the orphan receptor GPR55. palmidrol G protein-coupled receptor 55 Mus musculus
2 Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-alpha (peroxisome proliferator-activated receptors alpha) and the orphan receptor GPR55. Fatty Acids G protein-coupled receptor 55 Mus musculus
3 Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-alpha (peroxisome proliferator-activated receptors alpha) and the orphan receptor GPR55. Phospholipids G protein-coupled receptor 55 Mus musculus
4 Mechanistically, we found that palmitoylethanolamide, by activating GPR55, increases the expression of the phagocytosis receptor MerTK (proto-oncogene tyrosine-protein kinase MER) and enhances macrophage efferocytosis, indicative of proresolving properties. palmidrol G protein-coupled receptor 55 Mus musculus