Pub. Date : 2018 Dec 7
PMID : 30333228
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) has been attracting much attention as an important molecule for inducing axonal degeneration and neuronal cell death by causing loss of NAD (NADH). | nad (nadh) | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) has been attracting much attention as an important molecule for inducing axonal degeneration and neuronal cell death by causing loss of NAD (NADH). | nad (nadh) | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 4 | Here, we report that NAD+ cleavage activity of SARM1 is regulated by its own phosphorylation at serine 548. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 5 | Here, we report that NAD+ cleavage activity of SARM1 is regulated by its own phosphorylation at serine 548. | Serine | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 6 | The phosphorylation of SARM1 was mediated by c-jun N-terminal kinase (JNK) under oxidative stress conditions, resulting in inhibition of mitochondrial respiration concomitant with enhanced activity of NAD+ cleavage. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 7 | Nonphosphorylatable mutation of Ser-548 or treatment with a JNK inhibitor decreased SARM1 activity. | Serine | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 8 | These results indicate that JNK-mediated phosphorylation of SARM1 at Ser-548 is a regulator of SARM1 leading to inhibition of mitochondrial respiration. | Serine | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 9 | These results indicate that JNK-mediated phosphorylation of SARM1 at Ser-548 is a regulator of SARM1 leading to inhibition of mitochondrial respiration. | Serine | sterile alpha and TIR motif containing 1 | Homo sapiens |