Title : Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling.

Pub. Date : 2018

PMID : 30046369






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Propofol could alleviate H/R-induced intracellular calcium accumulation and MMP loss by inhibiting calcineurin activity and FKBP12.6-RyR disassociation in a concentration-dependent manner. Propofol FK506 binding protein 1b Mus musculus
2 Propofol could alleviate H/R-induced intracellular calcium accumulation and MMP loss by inhibiting calcineurin activity and FKBP12.6-RyR disassociation in a concentration-dependent manner. r FK506 binding protein 1b Mus musculus
3 Conclusions: Propofol protected hippocampal neurons from I/R injury through two independent signaling pathways, including the calcineurin/FKBP12.6-RyR/calcium overload pathway and the RhoA/Lats1/YAP/Bcl-2 pathway. Propofol FK506 binding protein 1b Mus musculus