Pub. Date : 2018 May-Jun
PMID : 29911172
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 2 | PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. | Dopamine | protein interacting with C kinase 1 | Mus musculus |
| 3 | Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine"s reinforcing actions. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 4 | Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine"s reinforcing actions. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 5 | In PICK1 knock-out (KO) mice, the acute locomotor response to a single injection of cocaine was markedly attenuated. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 6 | Moreover, in support of a role for PICK1 in neuroadaptive changes induced by cocaine, we observed diminished cocaine intake in a self-administration paradigm. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 7 | Moreover, in support of a role for PICK1 in neuroadaptive changes induced by cocaine, we observed diminished cocaine intake in a self-administration paradigm. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 8 | In summary, in addition to demonstrating a key role of PICK1 in mediating behavioral effects of cocaine, our data reveal a so far unappreciated role of PICK1 in DA homeostasis that possibly involves negative regulation of striatal TH levels. | Cocaine | protein interacting with C kinase 1 | Mus musculus |