PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29911172-0 2018 PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. Cocaine 50-57 protein interacting with C kinase 1 Mus musculus 0-5 29911172-0 2018 PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. Dopamine 75-83 protein interacting with C kinase 1 Mus musculus 0-5 29911172-1 2018 Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine"s reinforcing actions. Cocaine 247-254 protein interacting with C kinase 1 Mus musculus 0-35 29911172-1 2018 Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine"s reinforcing actions. Cocaine 247-254 protein interacting with C kinase 1 Mus musculus 37-42 29911172-1 2018 Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine"s reinforcing actions. Cocaine 247-254 discs large MAGUK scaffold protein 4 Mus musculus 109-115 29911172-1 2018 Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine"s reinforcing actions. Cocaine 247-254 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 218-221 29911172-3 2018 In PICK1 knock-out (KO) mice, the acute locomotor response to a single injection of cocaine was markedly attenuated. Cocaine 84-91 protein interacting with C kinase 1 Mus musculus 3-8 29911172-4 2018 Moreover, in support of a role for PICK1 in neuroadaptive changes induced by cocaine, we observed diminished cocaine intake in a self-administration paradigm. Cocaine 77-84 protein interacting with C kinase 1 Mus musculus 35-40 29911172-4 2018 Moreover, in support of a role for PICK1 in neuroadaptive changes induced by cocaine, we observed diminished cocaine intake in a self-administration paradigm. Cocaine 109-116 protein interacting with C kinase 1 Mus musculus 35-40 29911172-10 2018 In summary, in addition to demonstrating a key role of PICK1 in mediating behavioral effects of cocaine, our data reveal a so far unappreciated role of PICK1 in DA homeostasis that possibly involves negative regulation of striatal TH levels. Cocaine 96-103 protein interacting with C kinase 1 Mus musculus 55-60