Pub. Date : 2018 Aug 1
PMID : 29802821
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | microRNA-129-5p suppresses Adriamycin resistance in breast cancer by targeting SOX2. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 2 | microRNA-129-5p (miR-129-5p) has been considered a tumor-suppressive miRNA in several cancers, but its potential role in Adriamycin resistance in breast cancer has not been fully elucidate. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 3 | microRNA-129-5p (miR-129-5p) has been considered a tumor-suppressive miRNA in several cancers, but its potential role in Adriamycin resistance in breast cancer has not been fully elucidate. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 4 | By qRT-PCR assay, we revealed that the expression of miR-129-5p was significantly decreased in breast cancer tissues and Adriamycin-resistant breast cancer cells (MDA-MB-231/ADR, MCF-7/ADR). | Doxorubicin | microRNA 1295a | Homo sapiens |
| 5 | CCK-8, colony formation, wound healing, Transwell invasion, and flow cytometric profiles were examined to determine the influence of miR-129-5p on Adriamycin-resistant breast cancer in vitro. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 6 | The upregulation of miR-129-5p decreased the IC50 concentration of Adriamycin and invasion and promoted the apoptosis of MDA-MB-231/ADR cells in the presence of Adriamycin, whereas the upregulation of Sex-Determining Region Y-Box 2 (SOX2) reversed these effects. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 7 | The upregulation of miR-129-5p decreased the IC50 concentration of Adriamycin and invasion and promoted the apoptosis of MDA-MB-231/ADR cells in the presence of Adriamycin, whereas the upregulation of Sex-Determining Region Y-Box 2 (SOX2) reversed these effects. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 8 | Collectively, it was suggested that miR-129-5p suppresses Adriamycin resistance in breast cancer by directly targeting SOX2. | Doxorubicin | microRNA 1295a | Homo sapiens |