PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29802821-0 2018 microRNA-129-5p suppresses Adriamycin resistance in breast cancer by targeting SOX2. Doxorubicin 27-37 microRNA 1295a Homo sapiens 0-15 29802821-0 2018 microRNA-129-5p suppresses Adriamycin resistance in breast cancer by targeting SOX2. Doxorubicin 27-37 SRY-box transcription factor 2 Homo sapiens 79-83 29802821-3 2018 microRNA-129-5p (miR-129-5p) has been considered a tumor-suppressive miRNA in several cancers, but its potential role in Adriamycin resistance in breast cancer has not been fully elucidate. Doxorubicin 121-131 microRNA 1295a Homo sapiens 0-15 29802821-3 2018 microRNA-129-5p (miR-129-5p) has been considered a tumor-suppressive miRNA in several cancers, but its potential role in Adriamycin resistance in breast cancer has not been fully elucidate. Doxorubicin 121-131 microRNA 1295a Homo sapiens 17-27 29802821-4 2018 By qRT-PCR assay, we revealed that the expression of miR-129-5p was significantly decreased in breast cancer tissues and Adriamycin-resistant breast cancer cells (MDA-MB-231/ADR, MCF-7/ADR). Doxorubicin 121-131 microRNA 1295a Homo sapiens 53-63 29802821-5 2018 CCK-8, colony formation, wound healing, Transwell invasion, and flow cytometric profiles were examined to determine the influence of miR-129-5p on Adriamycin-resistant breast cancer in vitro. Doxorubicin 147-157 microRNA 1295a Homo sapiens 133-143 29802821-6 2018 The upregulation of miR-129-5p decreased the IC50 concentration of Adriamycin and invasion and promoted the apoptosis of MDA-MB-231/ADR cells in the presence of Adriamycin, whereas the upregulation of Sex-Determining Region Y-Box 2 (SOX2) reversed these effects. Doxorubicin 67-77 microRNA 1295a Homo sapiens 20-30 29802821-6 2018 The upregulation of miR-129-5p decreased the IC50 concentration of Adriamycin and invasion and promoted the apoptosis of MDA-MB-231/ADR cells in the presence of Adriamycin, whereas the upregulation of Sex-Determining Region Y-Box 2 (SOX2) reversed these effects. Doxorubicin 161-171 microRNA 1295a Homo sapiens 20-30 29802821-8 2018 Collectively, it was suggested that miR-129-5p suppresses Adriamycin resistance in breast cancer by directly targeting SOX2. Doxorubicin 58-68 microRNA 1295a Homo sapiens 36-46 29802821-8 2018 Collectively, it was suggested that miR-129-5p suppresses Adriamycin resistance in breast cancer by directly targeting SOX2. Doxorubicin 58-68 SRY-box transcription factor 2 Homo sapiens 119-123