Title : Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas.

Pub. Date : 2018 Jul 15

PMID : 29760046






6 Functional Relationships(s)
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1 The radiosensitizing effects of CUDC-907 were mediated by decreased NFkappaB/Forkhead box M1 (FOXM1) recruitment to promoters of genes involved in the DNA damage response; exogenous expression of NFkappaB/FOXM1 protected from CUDC-907-induced cytotoxicity. CUDC-907 nuclear factor kappa B subunit 1 Homo sapiens
2 The radiosensitizing effects of CUDC-907 were mediated by decreased NFkappaB/Forkhead box M1 (FOXM1) recruitment to promoters of genes involved in the DNA damage response; exogenous expression of NFkappaB/FOXM1 protected from CUDC-907-induced cytotoxicity. CUDC-907 forkhead box M1 Homo sapiens
3 The radiosensitizing effects of CUDC-907 were mediated by decreased NFkappaB/Forkhead box M1 (FOXM1) recruitment to promoters of genes involved in the DNA damage response; exogenous expression of NFkappaB/FOXM1 protected from CUDC-907-induced cytotoxicity. CUDC-907 forkhead box M1 Homo sapiens
4 The radiosensitizing effects of CUDC-907 were mediated by decreased NFkappaB/Forkhead box M1 (FOXM1) recruitment to promoters of genes involved in the DNA damage response; exogenous expression of NFkappaB/FOXM1 protected from CUDC-907-induced cytotoxicity. CUDC-907 nuclear factor kappa B subunit 1 Homo sapiens
5 The radiosensitizing effects of CUDC-907 were mediated by decreased NFkappaB/Forkhead box M1 (FOXM1) recruitment to promoters of genes involved in the DNA damage response; exogenous expression of NFkappaB/FOXM1 protected from CUDC-907-induced cytotoxicity. CUDC-907 forkhead box M1 Homo sapiens
6 The radiosensitizing effects of CUDC-907 were mediated by decreased NFkappaB/Forkhead box M1 (FOXM1) recruitment to promoters of genes involved in the DNA damage response; exogenous expression of NFkappaB/FOXM1 protected from CUDC-907-induced cytotoxicity. CUDC-907 nuclear factor kappa B subunit 1 Homo sapiens