Title : Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics.

Pub. Date : 2018 Jul

PMID : 29458047






1 Functional Relationships(s)
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1 Methadone is primarily metabolized in the liver by cytochrome P450 (CYP) enzymes, predominately by CYP2B6, followed by CYP3A4, 2C19, 2D6, and to a lesser extent, CYP2C18, 3A7, 2C8, 2C9, 3A5, and 1A2. Methadone cytochrome P450 family 2 subfamily C member 18 Homo sapiens