Title : Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma.

Pub. Date : 2018 Feb 1

PMID : 29411011






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CsA (10 muM) significantly inhibited the H2O2-induced expression of NFATc3 in normal and glaucoma LC cells. Cyclosporine nuclear factor of activated T cells 3 Homo sapiens
2 CsA (10 muM) significantly inhibited the H2O2-induced expression of NFATc3 in normal and glaucoma LC cells. Hydrogen Peroxide nuclear factor of activated T cells 3 Homo sapiens
3 CsA also reduced the H2O2-induced NFATc3 dephosphorylation (and nuclear translocation), and also suppressed the H2O2-induced elevation in profibrotic ECM genes (TGFbeta1, Col1A1, and periostin), both in normal and in glaucoma LC cells. Cyclosporine nuclear factor of activated T cells 3 Homo sapiens
4 CsA also reduced the H2O2-induced NFATc3 dephosphorylation (and nuclear translocation), and also suppressed the H2O2-induced elevation in profibrotic ECM genes (TGFbeta1, Col1A1, and periostin), both in normal and in glaucoma LC cells. Hydrogen Peroxide nuclear factor of activated T cells 3 Homo sapiens
5 CsA reduced the H2O2-induced enhancement in NFATc3 protein expression and nuclear translocation and the profibrotic gene expression both in normal and in glaucoma LC cells. Cyclosporine nuclear factor of activated T cells 3 Homo sapiens
6 CsA reduced the H2O2-induced enhancement in NFATc3 protein expression and nuclear translocation and the profibrotic gene expression both in normal and in glaucoma LC cells. Hydrogen Peroxide nuclear factor of activated T cells 3 Homo sapiens