Title : Osteogenic protein-1 attenuates the inflammatory cytokine-induced NP cell senescence through regulating the ROS/NF-κB pathway.

Pub. Date : 2018 Mar

PMID : 29367112






1 Functional Relationships(s)
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1 RESULTS: Compared with the control group, the inflammatory cytokine TNF-alpha significantly promoted NP cell senescence, reflected by the increase in SA-beta-Gal activity, G0/G1 phase fraction and senescence markers (p16 and p53) expression, and the decrease in telomerase activity and matrix macromolecules (aggrecan and collagen II) expression. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid tumor necrosis factor Rattus norvegicus