Title : Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy.

Pub. Date : 2017 Dec 7

PMID : 29181479






14 Functional Relationships(s)
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1 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. cds Scm like with four mbt domains 1 Homo sapiens
2 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. cds Scm like with four mbt domains 1 Homo sapiens
3 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. Carbon Scm like with four mbt domains 1 Homo sapiens
4 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. cds Scm like with four mbt domains 1 Homo sapiens
5 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. ru(ii) Scm like with four mbt domains 1 Homo sapiens
6 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. ru(ii) Scm like with four mbt domains 1 Homo sapiens
7 The photosensitizer and imaging agent Ru1 is decorated onto the nanocarrier CDs covalently. cds Scm like with four mbt domains 1 Homo sapiens
8 Ru1 and Ru1@CDs can penetrate into cancer cells through an energy-dependent mechanism and endocytosis, respectively. cds Scm like with four mbt domains 1 Homo sapiens
9 Both Ru1 and Ru1@CDs are capable of lysosome-targeted phosphorescence imaging and photodamage under either 450 nm (one-photon) or 810 nm (two-photon) excitation. cds Scm like with four mbt domains 1 Homo sapiens
10 Conjugation with CDs can increase the cellular uptake efficacy of Ru1. cds Scm like with four mbt domains 1 Homo sapiens
11 Mechanism investigations show that both Ru1 and Ru1@CDs can induce apoptosis through generation of reactive oxygen species and cathepsin-initiated apoptotic signaling pathways. cds Scm like with four mbt domains 1 Homo sapiens
12 Mechanism investigations show that both Ru1 and Ru1@CDs can induce apoptosis through generation of reactive oxygen species and cathepsin-initiated apoptotic signaling pathways. Reactive Oxygen Species Scm like with four mbt domains 1 Homo sapiens
13 Mechanism investigations show that both Ru1 and Ru1@CDs can induce apoptosis through generation of reactive oxygen species and cathepsin-initiated apoptotic signaling pathways. Reactive Oxygen Species Scm like with four mbt domains 1 Homo sapiens
14 Upon two-photon excitation, Ru1@CDs show better penetrability, as well as higher inhibitory effects on cancer cell growth in both 2D cell and 3D multicellular tumor spheroid models. cds Scm like with four mbt domains 1 Homo sapiens