PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29181479-2 2017 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. cds 44-47 Scm like with four mbt domains 1 Homo sapiens 40-43 29181479-2 2017 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. cds 44-47 Scm like with four mbt domains 1 Homo sapiens 119-122 29181479-2 2017 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. Carbon 60-66 Scm like with four mbt domains 1 Homo sapiens 40-43 29181479-2 2017 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. cds 77-80 Scm like with four mbt domains 1 Homo sapiens 40-43 29181479-2 2017 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. ru(ii) 103-109 Scm like with four mbt domains 1 Homo sapiens 40-43 29181479-2 2017 In this work, we constructed nanohybrid Ru1@CDs composed of carbon nanodots (CDs) and a phosphorescent Ru(ii) complex (Ru1) for one- and two-photon photodynamic therapy of cancer. ru(ii) 103-109 Scm like with four mbt domains 1 Homo sapiens 119-122 29181479-3 2017 The photosensitizer and imaging agent Ru1 is decorated onto the nanocarrier CDs covalently. cds 76-79 Scm like with four mbt domains 1 Homo sapiens 38-41 29181479-4 2017 Ru1 and Ru1@CDs can penetrate into cancer cells through an energy-dependent mechanism and endocytosis, respectively. cds 12-15 Scm like with four mbt domains 1 Homo sapiens 8-11 29181479-5 2017 Both Ru1 and Ru1@CDs are capable of lysosome-targeted phosphorescence imaging and photodamage under either 450 nm (one-photon) or 810 nm (two-photon) excitation. cds 17-20 Scm like with four mbt domains 1 Homo sapiens 13-16 29181479-6 2017 Conjugation with CDs can increase the cellular uptake efficacy of Ru1. cds 17-20 Scm like with four mbt domains 1 Homo sapiens 66-69 29181479-7 2017 Mechanism investigations show that both Ru1 and Ru1@CDs can induce apoptosis through generation of reactive oxygen species and cathepsin-initiated apoptotic signaling pathways. cds 52-55 Scm like with four mbt domains 1 Homo sapiens 48-51 29181479-7 2017 Mechanism investigations show that both Ru1 and Ru1@CDs can induce apoptosis through generation of reactive oxygen species and cathepsin-initiated apoptotic signaling pathways. Reactive Oxygen Species 99-122 Scm like with four mbt domains 1 Homo sapiens 40-43 29181479-7 2017 Mechanism investigations show that both Ru1 and Ru1@CDs can induce apoptosis through generation of reactive oxygen species and cathepsin-initiated apoptotic signaling pathways. Reactive Oxygen Species 99-122 Scm like with four mbt domains 1 Homo sapiens 48-51 29181479-8 2017 Upon two-photon excitation, Ru1@CDs show better penetrability, as well as higher inhibitory effects on cancer cell growth in both 2D cell and 3D multicellular tumor spheroid models. cds 32-35 Scm like with four mbt domains 1 Homo sapiens 28-31