Pub. Date : 2018 Feb
PMID : 29042084
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and phosphodiesterase 4C. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |
| 2 | Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and phosphodiesterase 4C. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |
| 3 | Knockdown of AC5 with siRNA attenuated the increase in cAMP levels in Pkd2-deficient renal epithelial cells. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |
| 4 | Importantly, cAMP levels and cAMP-dependent signaling were reduced in the kidneys of AC5/Pkd2 double mutant compared to the kidneys of Pkd2 single mutant mice. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |
| 5 | Importantly, cAMP levels and cAMP-dependent signaling were reduced in the kidneys of AC5/Pkd2 double mutant compared to the kidneys of Pkd2 single mutant mice. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |
| 6 | Thus, AC5 contributes importantly to increased renal cAMP levels and cyst growth in Pkd2 mutant mice, and inhibition of AC5 may be beneficial in the treatment of PKD. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |