PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29042084-2	2018	Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and phosphodiesterase 4C.	Cyclic AMP	83-87	adenylate cyclase 5	Mus musculus	118-143	
29042084-2	2018	Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and phosphodiesterase 4C.	Cyclic AMP	83-87	adenylate cyclase 5	Mus musculus	145-150	
29042084-2	2018	Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and phosphodiesterase 4C.	Cyclic AMP	83-87	polycystin 2, transient receptor potential cation channel	Mus musculus	153-165	
29042084-4	2018	Inhibition of AC5 reduces cAMP levels in Kif3a mutant cells, suggesting that AC5 may mediate the increase in cAMP in PKD.	Cyclic AMP	26-30	adenylate cyclase 5	Homo sapiens	14-17	
29042084-4	2018	Inhibition of AC5 reduces cAMP levels in Kif3a mutant cells, suggesting that AC5 may mediate the increase in cAMP in PKD.	Cyclic AMP	26-30	adenylate cyclase 5	Homo sapiens	77-80	
29042084-4	2018	Inhibition of AC5 reduces cAMP levels in Kif3a mutant cells, suggesting that AC5 may mediate the increase in cAMP in PKD.	Cyclic AMP	109-113	adenylate cyclase 5	Homo sapiens	14-17	
29042084-4	2018	Inhibition of AC5 reduces cAMP levels in Kif3a mutant cells, suggesting that AC5 may mediate the increase in cAMP in PKD.	Cyclic AMP	109-113	adenylate cyclase 5	Homo sapiens	77-80	
29042084-6	2018	Knockdown of AC5 with siRNA attenuated the increase in cAMP levels in Pkd2-deficient renal epithelial cells.	Cyclic AMP	55-59	adenylate cyclase 5	Mus musculus	13-16	
29042084-7	2018	Levels of cAMP and AC5 mRNA transcripts were elevated in the kidneys of mice with collecting duct-specific ablation of Pkd2.	Cyclic AMP	10-14	polycystin 2, transient receptor potential cation channel	Mus musculus	119-123	
29042084-9	2018	Importantly, cAMP levels and cAMP-dependent signaling were reduced in the kidneys of AC5/Pkd2 double mutant compared to the kidneys of Pkd2 single mutant mice.	Cyclic AMP	13-17	adenylate cyclase 5	Mus musculus	85-88	
29042084-9	2018	Importantly, cAMP levels and cAMP-dependent signaling were reduced in the kidneys of AC5/Pkd2 double mutant compared to the kidneys of Pkd2 single mutant mice.	Cyclic AMP	13-17	polycystin 2, transient receptor potential cation channel	Mus musculus	89-93	
29042084-9	2018	Importantly, cAMP levels and cAMP-dependent signaling were reduced in the kidneys of AC5/Pkd2 double mutant compared to the kidneys of Pkd2 single mutant mice.	Cyclic AMP	29-33	adenylate cyclase 5	Mus musculus	85-88	
29042084-9	2018	Importantly, cAMP levels and cAMP-dependent signaling were reduced in the kidneys of AC5/Pkd2 double mutant compared to the kidneys of Pkd2 single mutant mice.	Cyclic AMP	29-33	polycystin 2, transient receptor potential cation channel	Mus musculus	89-93	
29042084-11	2018	Thus, AC5 contributes importantly to increased renal cAMP levels and cyst growth in Pkd2 mutant mice, and inhibition of AC5 may be beneficial in the treatment of PKD.	Cyclic AMP	53-57	adenylate cyclase 5	Mus musculus	6-9