Pub. Date : 1988 Oct
PMID : 2902215
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Depletion of central dopamine content with alpha-methyl-p-tyrosine or reserpine, or selective destruction of nigrostriatal dopamine projections with bilateral 6-hydroxydopamine-induced substantia nigral lesions, partially blocked the immediate MDMA-induced reduction in rat striatal tryptophan hydroxylase (TPH) activity. | Oxidopamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 2 | Depletion of central dopamine content with alpha-methyl-p-tyrosine or reserpine, or selective destruction of nigrostriatal dopamine projections with bilateral 6-hydroxydopamine-induced substantia nigral lesions, partially blocked the immediate MDMA-induced reduction in rat striatal tryptophan hydroxylase (TPH) activity. | Oxidopamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 3 | In addition, the longer-term TPH deficits caused by a high single dose of MDMA were completely prevented by prior alpha-methyl-p-tyrosine or reserpine, and attenuated significantly by inhibition of dopamine uptake with the selective dopamine-uptake blocker GBR 12909. | N-Methyl-3,4-methylenedioxyamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 4 | In addition, the longer-term TPH deficits caused by a high single dose of MDMA were completely prevented by prior alpha-methyl-p-tyrosine or reserpine, and attenuated significantly by inhibition of dopamine uptake with the selective dopamine-uptake blocker GBR 12909. | alpha-Methyltyrosine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 5 | In addition, the longer-term TPH deficits caused by a high single dose of MDMA were completely prevented by prior alpha-methyl-p-tyrosine or reserpine, and attenuated significantly by inhibition of dopamine uptake with the selective dopamine-uptake blocker GBR 12909. | Reserpine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 6 | In addition, the longer-term TPH deficits caused by a high single dose of MDMA were completely prevented by prior alpha-methyl-p-tyrosine or reserpine, and attenuated significantly by inhibition of dopamine uptake with the selective dopamine-uptake blocker GBR 12909. | Dopamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 7 | In addition, the longer-term TPH deficits caused by a high single dose of MDMA were completely prevented by prior alpha-methyl-p-tyrosine or reserpine, and attenuated significantly by inhibition of dopamine uptake with the selective dopamine-uptake blocker GBR 12909. | Dopamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 8 | In addition, the longer-term TPH deficits caused by a high single dose of MDMA were completely prevented by prior alpha-methyl-p-tyrosine or reserpine, and attenuated significantly by inhibition of dopamine uptake with the selective dopamine-uptake blocker GBR 12909. | glutathione-bicarbonate-Ringer solution | tryptophan hydroxylase 1 | Rattus norvegicus |
| 9 | These results implicate endogenous drug-released dopamine as a partial mediator of the initial decrease in TPH activity caused by MDMA and as an important prerequisite to the development of long-term MDMA-induced neurotoxicity. | Dopamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 10 | These results implicate endogenous drug-released dopamine as a partial mediator of the initial decrease in TPH activity caused by MDMA and as an important prerequisite to the development of long-term MDMA-induced neurotoxicity. | N-Methyl-3,4-methylenedioxyamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |