| Protein Name | tryptophan hydroxylase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24848 |
| Gene Symbol | Tph1 |
| UniProt | P09810 (TPH1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
143
Total Number of Articles : 167 |
Description |
tryptophan hydroxylase 1 |
| Gene Summary |
Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Predicted to be located in cytoplasm. Predicted to be active in neuron projection. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and heroin dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |