Title : 5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR.

Pub. Date : 2017 Sep 11

PMID : 28894133






3 Functional Relationships(s)
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1 Silencing of FoxO3a with siRNA abrogated 5-MTP-mediated reduction of SA-beta-Gal and IL-6 secretion but not p21 or p16. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid forkhead box O3 Homo sapiens
2 Silencing of FoxO3a with siRNA abrogated 5-MTP-mediated reduction of SA-beta-Gal and IL-6 secretion but not p21 or p16. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid metallothionein 1B Homo sapiens
3 Rapamycin abrogated 5-MTP-mediated suppression of p16, p21, SA-beta-Gal and IL-6 and rise of BrdU incorporation. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid metallothionein 1B Homo sapiens