Title : Important role of adrenergic function in the development of analgesic tolerance to morphine in mice.

Pub. Date : 1986 Nov

PMID : 2881017






1 Functional Relationships(s)
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1 Pindolol (beta 1 + beta 2-blocker but is devoid of membrane stabilizing activity) suppressed the development of tolerance to morphine analgesia; however, d-propranolol, which possesses membrane stabilizing activity but lacks beta-blocking activity, could not prevent the development of tolerance. Pindolol hemoglobin, beta adult major chain Mus musculus