Pub. Date : 2017 Oct
PMID : 28765909
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells. | Auranofin | mucin 4, cell surface associated | Homo sapiens |
| 2 | In the present study, we reveal that the anticancer activity of auranofin in SKOV3 cells could be enhanced by the attenuation of MUC4 through the regulation of the Her2/Akt/FOXO3 pathway. | Auranofin | mucin 4, cell surface associated | Homo sapiens |
| 3 | Attenuation of MUC4 by siRNA transfection potentiated the antitumor effect of auranofin which was examined by performing in vitro assays such as WST-1, cell counting, colony formation, TUNEL and Annexin V staining. | Auranofin | mucin 4, cell surface associated | Homo sapiens |
| 4 | In addition, western blot analysis of the apoptosis-related proteins such as PARP1, caspase-3, Bim extra large (EL), Bax and Bcl2 revealed that the attenuation of MUC4 by siRNA transfection potentiates the pro-apoptotic activity of auranofin in SKOV3 cells. | Auranofin | mucin 4, cell surface associated | Homo sapiens |
| 5 | Collectively, auranofin could regulate the Her2/Akt/FOXO3 signaling pathway in SKOV3 cells and be used as a potential antitumor agent considering the expression of MUC4 in ovarian cancer patients. | Auranofin | mucin 4, cell surface associated | Homo sapiens |