Title : Epidermal growth factor-stimulated DNA synthesis requires an influx of extracellular calcium.

Pub. Date : 1988 Oct

PMID : 2851595






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Fura-2-loaded T51B cells responded with an increase in [Ca2+]i to EGF (5-50 ng/ml) that was blocked by low (25 microM) extracellular Ca2+ or by pretreatment with 50 microM La3+ to inhibit plasma membrane Ca2+ flux. lanthanum(3+) epidermal growth factor Homo sapiens
2 Low extracellular Ca2+ or addition of La3+ prevented the EGF-stimulated rise in labeled nuclei, indicating that a movement of Ca2+ into the cell was required for DNA synthesis. lanthanum(3+) epidermal growth factor Homo sapiens