Pub. Date : 2017 Mar 28
PMID : 28423521
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. | EHT 1864 | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. | EHT 1864 | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. | EHT 1864 | midkine | Mus musculus |
| 4 | EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. | EHT 1864 | mitogen-activated protein kinase 1 | Mus musculus |
| 5 | Interestingly, EHT1864 decreased activation of the mTORC1 substrate p70S6K earlier than AKT inhibition, suggesting that Rac may activate mTORC1/p70S6K independently of AKT. | EHT 1864 | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | Interestingly, EHT1864 decreased activation of the mTORC1 substrate p70S6K earlier than AKT inhibition, suggesting that Rac may activate mTORC1/p70S6K independently of AKT. | EHT 1864 | ribosomal protein S6 kinase, polypeptide 1 | Mus musculus |
| 7 | Interestingly, EHT1864 decreased activation of the mTORC1 substrate p70S6K earlier than AKT inhibition, suggesting that Rac may activate mTORC1/p70S6K independently of AKT. | EHT 1864 | CREB regulated transcription coactivator 1 | Mus musculus |
| 8 | Interestingly, EHT1864 decreased activation of the mTORC1 substrate p70S6K earlier than AKT inhibition, suggesting that Rac may activate mTORC1/p70S6K independently of AKT. | EHT 1864 | ribosomal protein S6 kinase, polypeptide 1 | Mus musculus |
| 9 | Comparison of the growth-inhibitory profile of EHT1864 to 137 other anti-cancer drugs across 656 cancer cell lines revealed significant correlation with the p70S6K inhibitor PF-4708671. | EHT 1864 | ribosomal protein S6 kinase, polypeptide 1 | Mus musculus |
| 10 | We confirmed that Rac complexes contain MEK1/2 and ERK1/2, but also contain p70S6K; these interactions were disrupted by EHT1864. | EHT 1864 | mitogen-activated protein kinase kinase 1 | Mus musculus |
| 11 | We confirmed that Rac complexes contain MEK1/2 and ERK1/2, but also contain p70S6K; these interactions were disrupted by EHT1864. | EHT 1864 | ribosomal protein S6 kinase, polypeptide 1 | Mus musculus |
| 12 | EHT1864 suppressed growth of HER2+ tumors, and enhanced response to anti-estrogen treatment in ER+ tumors. | EHT 1864 | erb-b2 receptor tyrosine kinase 2 | Mus musculus |