Pub. Date : 2017
PMID : 28406939
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since NeuroD1 is known to bind to and activate E-box of the Pomc promoter, we next examined the effect of DEX on NeuroD1 expression. | Dexamethasone | neurogenic differentiation 1 | Mus musculus |
| 2 | Interestingly, DEX dose-dependently inhibited NeuroD1 mRNA expression, mouse NeuroD1 promoter (-2.2-kb) activity, and NeuroD1 protein expression in AtT20 cells. | Dexamethasone | neurogenic differentiation 1 | Mus musculus |
| 3 | Interestingly, DEX dose-dependently inhibited NeuroD1 mRNA expression, mouse NeuroD1 promoter (-2.2-kb) activity, and NeuroD1 protein expression in AtT20 cells. | Dexamethasone | neurogenic differentiation 1 | Mus musculus |
| 4 | Interestingly, DEX dose-dependently inhibited NeuroD1 mRNA expression, mouse NeuroD1 promoter (-2.2-kb) activity, and NeuroD1 protein expression in AtT20 cells. | Dexamethasone | neurogenic differentiation 1 | Mus musculus |
| 5 | In addition, we confirmed the inhibitory effect of DEX on the interaction of NeuroD1 and E-box on Pomc promoter by chromatin immunoprecipitation (ChIP) assay. | Dexamethasone | neurogenic differentiation 1 | Mus musculus |
| 6 | Finally, overexpression of mouse NeuroD1 could rescue the DEX-mediated inhibition of Pomc mRNA expression and Pomc promoter activity. | Dexamethasone | neurogenic differentiation 1 | Mus musculus |