Title : Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition.

Pub. Date : 2017 May 9

PMID : 28404876






1 Functional Relationships(s)
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1 We show that the shedding of MICA, MICB and ULBP2 is inhibited by the increased expression of TIMP3, an ADAM17 inhibitor, after DAC treatment. Decitabine MHC class I polypeptide-related sequence B Homo sapiens