Title : Regulation of beta-adrenoceptor number and subtype in 3T3-L1 preadipocytes by sodium butyrate.

Pub. Date : 1987 Nov 3

PMID : 2826186






2 Functional Relationships(s)
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1 In mouse 3T3-L1 preadipocytes, the glucocorticoid dexamethasone has been shown to promote a switch in beta-adrenoceptor subtype expression from beta 1 to beta 2 and to increase the total number of beta-adrenoceptors. Dexamethasone hemoglobin, beta adult major chain Mus musculus
2 Incubation of preadipocytes with 2-10 mM butyrate for 24-48 h promoted a dose- and time-dependent switch in beta-adrenoceptor subtype from a near equal mixture of beta 1 and beta 2 to greater than 85% beta 2 and caused an approximate doubling of the receptor number. Butyrates hemoglobin, beta adult major chain Mus musculus