Pub. Date : 1987 Nov
PMID : 2824558
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 2 | The regulation of the expression of interstitial collagenase and tissue inhibitor of metalloproteinases (TIMP) was examined in response to both retinoid compounds and glucocorticoids. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 3 | The regulation of the expression of interstitial collagenase and tissue inhibitor of metalloproteinases (TIMP) was examined in response to both retinoid compounds and glucocorticoids. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 4 | Effective retinoids induced a dose-dependent, specific increase in the production of TIMP of approximately two- to threefold by monolayer cultures of human fibroblasts derived from various tissues, while simultaneously causing a decrease in collagenase secretion of similar magnitude. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 5 | The retinoid effect on TIMP production was mediated via an increased biosynthesis of new inhibitor protein. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 6 | Similarly, increased steady state levels of TIMP messenger RNA (mRNA) accompanied by decreased quantities of collagenase mRNA were demonstrated, suggesting transcriptional control of the retinoid action. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 7 | The data suggest that retinoids co-regulate the expression of collagenase and TIMP, and do so in an inverse manner. | Retinoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |