Title : ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis.

Pub. Date : 2018 Apr

PMID : 28053052






1 Functional Relationships(s)
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1 Also in mice, irinotecan treatment induced hepatic ACOX1 expression, ERK phosphorylation and inflammation, as well as impairment of autophagy and significant steatosis. Irinotecan acyl-Coenzyme A oxidase 1, palmitoyl Mus musculus