Pub. Date : 2017 Jun
PMID : 27896399
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Seven isoforms were capable of metabolizing triclosan, with the order of activity being CYP1A2 > CYP2B6 > CYP2C19 > CYP2D6 CYP1B1 > CYP2C18 CYP1A1. | Triclosan | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 2 | Consistent with the in vitro screening data, triclosan was extensively metabolized in HepG2 cells overexpressing CYP1A2, CYP2B6, CYP2C19, CYP2D6, and CYP2C18, and these cells were much more resistant to triclosan-induced cytotoxicity compared to vector cells, suggesting that CYP-mediated metabolism of triclosan attenuated its cytotoxicity. | Triclosan | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |