Title : Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone.

Pub. Date : 2017 Aug

PMID : 27853934






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Clozapine-N-oxide inhibited CYP2B6 and CYP2C19 pathways with IC50 of 8.3 and 8.7 microM, respectively. clozapine N-oxide cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 Clozapine-N-oxide inhibited CYP2B6 and CYP2C19 pathways with IC50 of 8.3 and 8.7 microM, respectively. clozapine N-oxide cytochrome P450 family 2 subfamily C member 19 Homo sapiens
3 Co-incubation of clozapine-N-oxide with clozapine potentiated CYP2B6/2C19 pathways; however, incubation of voriconazole-N-oxide with voriconazole did not appear to potentiate the CYP pathways because parent caused an inhibition of almost 80%. clozapine N-oxide cytochrome P450 family 2 subfamily B member 6 Homo sapiens