Pub. Date : 2016 Oct 27
PMID : 27760115
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. | tet | left right determination factor 1 | Mus musculus |
| 2 | Moreover, reduction in Lefty gene expression is linked to elevated DNA methylation, as both Lefty-Nodal signalling and normal morphogenesis are largely restored in Tet-deficient embryos when the Dnmt3a and Dnmt3b genes are disrupted. | tetramethylenedisulfotetramine | left right determination factor 1 | Mus musculus |
| 3 | Moreover, reduction in Lefty gene expression is linked to elevated DNA methylation, as both Lefty-Nodal signalling and normal morphogenesis are largely restored in Tet-deficient embryos when the Dnmt3a and Dnmt3b genes are disrupted. | tetramethylenedisulfotetramine | left right determination factor 1 | Mus musculus |
| 4 | Taken together, our results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B. | tet | left right determination factor 1 | Mus musculus |
| 5 | Taken together, our results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B. | 5-Methylcytosine | left right determination factor 1 | Mus musculus |