| Protein Name | left right determination factor 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13590 |
| Gene Symbol | Lefty1 |
| UniProt | Q64280 (LFTY1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
19
Total Number of Articles : 13 |
Description |
left right determination factor 1 |
| Gene Summary |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. Mice lacking a functional copy of this gene exhibit embryonic lethality and defects in left-right patterning. [provided by RefSeq, Aug 2016] |
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