Title : Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.

Pub. Date : 2016 Nov 1

PMID : 27391798






1 Functional Relationships(s)
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1 In particular, TCR signal strength that elicits positive selection induces Twist2 expression via the Ca2+-Cacineurin-NFATc3 pathway, whereas strength of the TCR signal that results in negative selection abolishes NFATc3-dependent Twist2 induction via specific activation of the JNK pathway. cacineurin nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Mus musculus