Title : ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells.

Pub. Date : 2016 Jul 1

PMID : 27190058






4 Functional Relationships(s)
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1 ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells. Calcium nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Mus musculus
2 In the present study, we tested the hypothesis that ASIC1 contributes to NFATc3 nuclear translocation in PASMC in a PICK1-dependent manner. pasmc nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Mus musculus
3 Inhibition of PICK1 by using FSC231 abolished ET-1-induced and ionomycin-induced NFATc3 nuclear import, but it did not alter ET-1-mediated Ca(2+) responses, suggesting that PICK1 acts downstream of Ca(2+) influx. FSC 231 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Mus musculus
4 Inhibition of PICK1 by using FSC231 abolished ET-1-induced and ionomycin-induced NFATc3 nuclear import, but it did not alter ET-1-mediated Ca(2+) responses, suggesting that PICK1 acts downstream of Ca(2+) influx. Ionomycin nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Mus musculus