Pub. Date : 2016 Jul 1
PMID : 27190058
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells. | Calcium | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 | Mus musculus |
2 | In the present study, we tested the hypothesis that ASIC1 contributes to NFATc3 nuclear translocation in PASMC in a PICK1-dependent manner. | pasmc | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 | Mus musculus |
3 | Inhibition of PICK1 by using FSC231 abolished ET-1-induced and ionomycin-induced NFATc3 nuclear import, but it did not alter ET-1-mediated Ca(2+) responses, suggesting that PICK1 acts downstream of Ca(2+) influx. | FSC 231 | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 | Mus musculus |
4 | Inhibition of PICK1 by using FSC231 abolished ET-1-induced and ionomycin-induced NFATc3 nuclear import, but it did not alter ET-1-mediated Ca(2+) responses, suggesting that PICK1 acts downstream of Ca(2+) influx. | Ionomycin | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 | Mus musculus |