Pub. Date : 2016 Aug
PMID : 26883802
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression. | Uridine Diphosphate Sugars | hyaluronan synthase 3 | Homo sapiens |
| 2 | For the very first time, the present study demonstrated a rapid recycling of HAS3 between PM and endosomes, controlled by the cytosolic levels of the HAS substrates UDP-GlcUA and UDP-GlcNAc. | Uridine Diphosphate Glucuronic Acid | hyaluronan synthase 3 | Homo sapiens |
| 3 | For the very first time, the present study demonstrated a rapid recycling of HAS3 between PM and endosomes, controlled by the cytosolic levels of the HAS substrates UDP-GlcUA and UDP-GlcNAc. | Uridine Diphosphate N-Acetylglucosamine | hyaluronan synthase 3 | Homo sapiens |
| 4 | Depletion of UDP-GlcNAc or UDP-GlcUA shifted the balance towards HAS3 endocytosis, and inhibition of hyaluronan synthesis. | Uridine Diphosphate N-Acetylglucosamine | hyaluronan synthase 3 | Homo sapiens |
| 5 | Depletion of UDP-GlcNAc or UDP-GlcUA shifted the balance towards HAS3 endocytosis, and inhibition of hyaluronan synthesis. | Uridine Diphosphate Glucuronic Acid | hyaluronan synthase 3 | Homo sapiens |
| 6 | In contrast, UDP-GlcNAc surplus suppressed endocytosis and lysosomal decay of HAS3, favoring its retention in PM, stimulating hyaluronan synthesis, and HAS3 shedding in extracellular vesicles. | Uridine Diphosphate N-Acetylglucosamine | hyaluronan synthase 3 | Homo sapiens |
| 7 | In contrast, UDP-GlcNAc surplus suppressed endocytosis and lysosomal decay of HAS3, favoring its retention in PM, stimulating hyaluronan synthesis, and HAS3 shedding in extracellular vesicles. | Uridine Diphosphate N-Acetylglucosamine | hyaluronan synthase 3 | Homo sapiens |
| 8 | In contrast, UDP-GlcNAc surplus suppressed endocytosis and lysosomal decay of HAS3, favoring its retention in PM, stimulating hyaluronan synthesis, and HAS3 shedding in extracellular vesicles. | Hyaluronic Acid | hyaluronan synthase 3 | Homo sapiens |
| 9 | The concentration of UDP-GlcNAc also controlled the level of O-GlcNAc modification of HAS3. | Uridine Diphosphate N-Acetylglucosamine | hyaluronan synthase 3 | Homo sapiens |
| 10 | Increasing O-GlcNAcylation reproduced the effects of UDP-GlcNAc surplus on HAS3 trafficking, while its suppression showed the opposite effects, indicating that O-GlcNAc signaling is associated to UDP-GlcNAc supply. | Uridine Diphosphate N-Acetylglucosamine | hyaluronan synthase 3 | Homo sapiens |
| 11 | In general, changes in glucose metabolism, realized through UDP-sugar contents and O-GlcNAc signaling, are important in HAS3 trafficking, hyaluronan synthesis, and correlates with melanoma progression. | Glucose | hyaluronan synthase 3 | Homo sapiens |