Title : Dual Effects of Bisphosphonates on Ectopic Skin and Vascular Soft Tissue Mineralization versus Bone Microarchitecture in a Mouse Model of Generalized Arterial Calcification of Infancy.

Pub. Date : 2016 Jan

PMID : 26763447






2 Functional Relationships(s)
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1 Generalized arterial calcification of infancy is an intractable ectopic mineralization disorder caused by mutations in the ENPP1 gene, resulting in reduced plasma inorganic pyrophosphate (PPi) levels. diphosphoric acid ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus
2 Collectively, these results suggest that bisphosphonate treatment may be beneficial by a dual effect for preventing ectopic soft tissue mineralization while correcting decreased bone mineralization in generalized arterial calcification of infancy caused by ENPP1 mutations. Diphosphonates ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus