Protein Name ectonucleotide pyrophosphatase/phosphodiesterase 1
Organism Mus musculus
Gene ID 18605
Gene Symbol

Enpp1

UniProt P06802 (ENPP1_MOUSE), G3X9S2 (G3X9S2_MOUSE), A0A0R4J1Q7 (A0A0R4J1Q7_MOUSE)
Relationships Total Number of functionally related compound(s) : 63
Total Number of Articles : 75
Description

ectonucleotide pyrophosphatase/phosphodiesterase 1

Gene Summary

This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

synonyms
  • ectonucleotide pyrophosphatase/phosphodiesterase family member 1
  • NPPase
  • alkaline phosphodiesterase I
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Properties