Pub. Date : 2016
PMID : 26752183
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide is synthesized in yeast by two redundant acyl-CoA dependent synthases, Lag1 and Lac1. | Ceramides | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 2 | In lag1 lac1 cells, free fatty acids and sphingoid bases are elevated, and ceramides are produced through the redundant alkaline ceramidases Ypc1 and Ydc1, working backwards. | Fatty Acids, Nonesterified | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 3 | In lag1 lac1 cells, free fatty acids and sphingoid bases are elevated, and ceramides are produced through the redundant alkaline ceramidases Ypc1 and Ydc1, working backwards. | Sphingosine | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 4 | In lag1 lac1 cells, free fatty acids and sphingoid bases are elevated, and ceramides are produced through the redundant alkaline ceramidases Ypc1 and Ydc1, working backwards. | Ceramides | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 5 | Here we show that these residual sphingolipids are not synthesized by YPR114w or YJR116w, proteins of unknown function showing a high degree of homology to Lag1 and Lac1. | Sphingolipids | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 6 | Indeed, the hextuple lag1 lac1 ypc1 ydc1 ypr114w yjr116w mutant still contains ceramides and complex sphingolipids. | Ceramides | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 7 | Indeed, the hextuple lag1 lac1 ypc1 ydc1 ypr114w yjr116w mutant still contains ceramides and complex sphingolipids. | Sphingolipids | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |