Title : The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model.

Pub. Date : 2015

PMID : 26509067






2 Functional Relationships(s)
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1 METHODS: The H2 blocker famotidine was orally administered to Enpp1 (ttw/ttw) mice, a model of OPLL, at either 4 or 15 weeks of age. Famotidine ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus
2 RESULTS: Oral administration of famotidine suppressed the progression of OPLL-like ectopic ossification and reduced mortality in Enpp1 (ttw/ttw) mice when administration began at 4 weeks of age, early in the development of ossification. Famotidine ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus