Pub. Date : 2015 Aug 11
PMID : 26259688
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Therefore, our goal in the present study was to examine the role of microRNA-9 (miR-9) in regulating Nav1.1/Nav1.2 trafficking under CBH generated by bilateral common carotid artery occlusion (2VO). | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | membrane associated ring-CH-type finger 8 | Rattus norvegicus |
2 | Therefore, our goal in the present study was to examine the role of microRNA-9 (miR-9) in regulating Nav1.1/Nav1.2 trafficking under CBH generated by bilateral common carotid artery occlusion (2VO). | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | sodium voltage-gated channel alpha subunit 2 | Rattus norvegicus |
3 | RESULTS: The impairment of Nav1.1/Nav1.2 trafficking and decreased expression of Navbeta2 were found in the hippocampi and cortices of rats following CBH generated by bilateral 2VO. | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | sodium voltage-gated channel alpha subunit 2 | Rattus norvegicus |
4 | MiR-9 was increased in both the hippocampi and cortices of rats following CBH by qRT-PCR. | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | membrane associated ring-CH-type finger 8 | Rattus norvegicus |
5 | CONCLUSIONS: We conclude that miR-9 may play a key role in regulating the process of Nav1.1/Nav1.2 trafficking via targeting on Navbeta2 protein in 2VO rats at post-transcriptional level, and inhibition of miR-9 may be a potentially valuable approach to prevent Nav1.1/Nav1.2 trafficking disturbance induced by CBH. | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | membrane associated ring-CH-type finger 8 | Rattus norvegicus |
6 | CONCLUSIONS: We conclude that miR-9 may play a key role in regulating the process of Nav1.1/Nav1.2 trafficking via targeting on Navbeta2 protein in 2VO rats at post-transcriptional level, and inhibition of miR-9 may be a potentially valuable approach to prevent Nav1.1/Nav1.2 trafficking disturbance induced by CBH. | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | sodium voltage-gated channel alpha subunit 2 | Rattus norvegicus |
7 | CONCLUSIONS: We conclude that miR-9 may play a key role in regulating the process of Nav1.1/Nav1.2 trafficking via targeting on Navbeta2 protein in 2VO rats at post-transcriptional level, and inhibition of miR-9 may be a potentially valuable approach to prevent Nav1.1/Nav1.2 trafficking disturbance induced by CBH. | S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE | sodium voltage-gated channel alpha subunit 2 | Rattus norvegicus |