Title : MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting NavĪ²2 protein coding region in rat with chronic brain hypoperfusion.

Pub. Date : 2015 Aug 11

PMID : 26259688






7 Functional Relationships(s)
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1 Therefore, our goal in the present study was to examine the role of microRNA-9 (miR-9) in regulating Nav1.1/Nav1.2 trafficking under CBH generated by bilateral common carotid artery occlusion (2VO). S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE membrane associated ring-CH-type finger 8 Rattus norvegicus
2 Therefore, our goal in the present study was to examine the role of microRNA-9 (miR-9) in regulating Nav1.1/Nav1.2 trafficking under CBH generated by bilateral common carotid artery occlusion (2VO). S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE sodium voltage-gated channel alpha subunit 2 Rattus norvegicus
3 RESULTS: The impairment of Nav1.1/Nav1.2 trafficking and decreased expression of Navbeta2 were found in the hippocampi and cortices of rats following CBH generated by bilateral 2VO. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE sodium voltage-gated channel alpha subunit 2 Rattus norvegicus
4 MiR-9 was increased in both the hippocampi and cortices of rats following CBH by qRT-PCR. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE membrane associated ring-CH-type finger 8 Rattus norvegicus
5 CONCLUSIONS: We conclude that miR-9 may play a key role in regulating the process of Nav1.1/Nav1.2 trafficking via targeting on Navbeta2 protein in 2VO rats at post-transcriptional level, and inhibition of miR-9 may be a potentially valuable approach to prevent Nav1.1/Nav1.2 trafficking disturbance induced by CBH. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE membrane associated ring-CH-type finger 8 Rattus norvegicus
6 CONCLUSIONS: We conclude that miR-9 may play a key role in regulating the process of Nav1.1/Nav1.2 trafficking via targeting on Navbeta2 protein in 2VO rats at post-transcriptional level, and inhibition of miR-9 may be a potentially valuable approach to prevent Nav1.1/Nav1.2 trafficking disturbance induced by CBH. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE sodium voltage-gated channel alpha subunit 2 Rattus norvegicus
7 CONCLUSIONS: We conclude that miR-9 may play a key role in regulating the process of Nav1.1/Nav1.2 trafficking via targeting on Navbeta2 protein in 2VO rats at post-transcriptional level, and inhibition of miR-9 may be a potentially valuable approach to prevent Nav1.1/Nav1.2 trafficking disturbance induced by CBH. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE sodium voltage-gated channel alpha subunit 2 Rattus norvegicus