Pub. Date : 1989 Jul-Aug
PMID : 2571477
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These observations suggested the potential involvement of the male-specific cytochrome P-450 UT-A and the P-450 PCN-E in the metabolism of this pyrrolizidine alkaloid. | PYRROLIZIDINE | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | Reconstituted rat P-450 UT-A exhibited a high rate of N-oxidation (15 nmol min-1 nmol P-450-1) which is almost 3-fold higher than the turnover number observed with male rat liver microsomes. | Nitrogen | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 3 | In contrast, rat P-450 UT-A displayed a much lower activity toward necine pyrrole [+/-)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine, DHP) formation (1.0 nmol min-1 nmol P-450-1). | necine pyrrole [+/-)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5h-pyrrolizine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 4 | Rabbit antibody to rat P-450 UT-A inhibited the senecionine-N-oxidation activity of untreated male rat liver microsomes by 60%, with lesser inhibition of DHP production. | senecionine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 5 | Rabbit antibody to rat P-450 UT-A inhibited the senecionine-N-oxidation activity of untreated male rat liver microsomes by 60%, with lesser inhibition of DHP production. | Nitrogen | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |