Pub. Date : 1989 Jun 20
PMID : 2570704
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of MK-801 on the decrease in tryptophan hydroxylase induced by methamphetamine and its methylenedioxy analog. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 2 | The role of N-methyl-D-aspartate (NMDA) receptors in the decrease in neostriatal tryptophan hydroxylase (TPH) activity induced by repeated high doses of methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA) was evaluated. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 3 | The role of N-methyl-D-aspartate (NMDA) receptors in the decrease in neostriatal tryptophan hydroxylase (TPH) activity induced by repeated high doses of methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA) was evaluated. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 4 | These treatments with methamphetamine or MDMA reduced neostriatal TPH activity to 26 and 34% of control, respectively. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 5 | Coadministration of MK-801 (2.5 mg/kg) significantly attenuated the methamphetamine-induced decrease in TPH activity (66% of control), but did not alter the effect of MDMA. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 6 | This study suggests that excitatory amino acids may participate in the methamphetamine-induced decline in central TPH activity, and that the mechanism by which MDMA and methamphetamine decreases TPH activity may differ. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |
| 7 | This study suggests that excitatory amino acids may participate in the methamphetamine-induced decline in central TPH activity, and that the mechanism by which MDMA and methamphetamine decreases TPH activity may differ. | Methamphetamine | tryptophan hydroxylase 1 | Rattus norvegicus |