Title : Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3',5'-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates.

Pub. Date : 1989

PMID : 2556881






9 Functional Relationships(s)
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1 The effect of dibutyryladenosine 3",5"-cyclic monophosphate (dibutyryl cAMP) on the expression of glutathione S-transferase placental type (GST-P) was examined in rat glioma cell line using an immunohistochemical technique. Bucladesine glutathione S-transferase pi 1 Rattus norvegicus
2 The effect of dibutyryladenosine 3",5"-cyclic monophosphate (dibutyryl cAMP) on the expression of glutathione S-transferase placental type (GST-P) was examined in rat glioma cell line using an immunohistochemical technique. Bucladesine glutathione S-transferase pi 1 Rattus norvegicus
3 However, treatment with 1 mM dibutyryl cAMP produced GST-P expression in about 50% of the cells, as well as some morphological changes. Bucladesine glutathione S-transferase pi 1 Rattus norvegicus
4 The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC). Bucladesine glutathione S-transferase pi 1 Rattus norvegicus
5 The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC). allyl isothiocyanate glutathione S-transferase pi 1 Rattus norvegicus
6 The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC). allyl isothiocyanate glutathione S-transferase pi 1 Rattus norvegicus
7 The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC). benzyl isothiocyanate glutathione S-transferase pi 1 Rattus norvegicus
8 The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC). benzyl isothiocyanate glutathione S-transferase pi 1 Rattus norvegicus
9 With these combinated treatments, almost all cultured cells showed a strong positive reaction for GST-P, although AITC or BITC alone elicited GST-P in only 5% of the cultured cells. benzyl isothiocyanate glutathione S-transferase pi 1 Rattus norvegicus